蕁麻疹
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慢性蕁麻疹の病態生理の研究
慢性蕁麻疹は5人に1人が罹患するといわれている国民病ですが、病態生理はよく分かっていません。当科ではアレルギーセンターを中心に慢性蕁麻疹の病態生理を研究しています。慢性蕁麻疹の半数は自己免疫性といわれており、自己血清皮内テストにて診断できます。我々は慢性特発性蕁麻疹患者においてマスト細胞、好塩基球の高親和性IgE受容体(FceRI)のα鎖に対する自己抗体や抗IgE抗体の解析を行っております。今後も研究を継続して行います。
掲載論文
- Nishimori N, Toyoshima S, Sasaki-Sakamoto T, Hayama K, Terui T, Okayama Y. Serum level of hemokinin-1 is significantly lower in patients with chronic spontaneous urticaria than in healthy subjects. Allergol Int. 2021 Oct;70(4):480-488. doi: 10.1016/j.alit.2021.05.002. Epub 2021 Jun 3. PMID: 34090787.
- Hayama K, Fujita H, Asai-Sato M, Kawana K, Terui T. Successful treatment of intractable chronic spontaneous urticaria with omalizumab in a patient with ovarian cancer. Eur J Dermatol. 2021 Feb 1;31(1):100-101. doi: 10.1684/ejd.2020.3959. PMID: 33459258; PMCID: PMC8120768.
- Endo T, Toyoshima S, Hayama K, Tagui M, Niwa Y, Ito M, Terui T, Okayama Y. Relationship between changes in the 7-day urticaria activity score after treatment with omalizumab and the responsiveness of basophils to FcεRI stimulation in patients with chronic spontaneous urticaria. Asia Pac Allergy. 2020 Apr 10;10(2):e12. doi: 10.5415/apallergy.2020.10.e12. PMID: 32411577; PMCID: PMC7203440.
- Endo T, Toyoshima S, Hayama K, Terui T, Okayama Y. Patients who have anti-FcεRI nonreactive basophils do not represent patients with severe chronic spontaneous urticaria. J Allergy Clin Immunol Pract. 2020 Feb;8(2):824-825.e2. doi: 10.1016/j.jaip.2019.11.032. PMID: 32037120.
- Izaki S, Toyoshima S, Endo T, Kanegae K, Nunomura S, Kashiwakura JI, Sasaki-Sakamoto T, Nakamura R, Akiyama H, Ra C, Hayama K, Terui T, Okayama Y. Differentiation between control subjects and patients with chronic spontaneous urticaria based on the ability of anti-IgE autoantibodies (AAbs) to induce FcεRI crosslinking, as compared to anti-FcεRIα AAbs. Allergol Int. 2019 Jul;68(3):342-351. doi: 10.1016/j.alit.2019.01.003. Epub 2019 Feb 22. PMID: 30803853.
- Endo T, Toyoshima S, Kanegae K, Izaki S, Nishimori N, Ito M, Sugai K, Hayama K, Terui T, Okayama Y. Identification of biomarkers for predicting the response to cyclosporine A therapy in patients with chronic spontaneous urticaria. Allergol Int. 2019 Apr;68(2):270-273. doi: 10.1016/j.alit.2018.09.006. Epub 2018 Oct 22. PMID: 30355455.
- Fujisawa D, Kashiwakura J, Kita H, Kikukawa Y, Fujitani Y, Sasaki-Sakamoto T, Kuroda K, Nunomura S, Hayama K, Terui T, Ra C, Okayama Y. Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. J Allergy Clin Immunol. 2014 Sep;134(3):622-633.e9. doi: 10.1016/j.jaci.2014.05.004. Epub 2014 Jun 19. PMID: 24954276.
- Hatada Y, Kashiwakura J, Hayama K, Fujisawa D, Sasaki-Sakamoto T, Terui T, Ra C, Okayama Y. Significantly high levels of anti-dsDNA immunoglobulin E in sera and the ability of dsDNA to induce the degranulation of basophils from chronic urticaria patients. Int Arch Allergy Immunol. 2013;161 Suppl 2:154-8. doi: 10.1159/000350388. Epub 2013 May 29. PMID: 23711867.